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As you can see, vitamin B12 is the junction between the methionine cycle and the folate cycle

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HEK293 cells were treated for 10 min with HGF+/- Nle-X-Ile-(6) amino-hexanoic amide analogs at the indicated concentrations

Contrary to these results, a subsequent randomized double-blind placebo-controlled clinical trial, wherein IN-OXT was administered daily within 12 days of trauma for 8 days and assessments, conducted at baseline and 1.5 months post-trauma, found that IN-OXT reduced PTSD, depression, and anxiety, even at follow-ups 6 months post-trauma [177,178]