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Of note, a growing number of studies support mitochondrial metabolism of LAC as a common culprit underlying psychiatric and neurodegenerative diseases such as MDD and AD as well as obesity, making it important to further understand mechanisms for the development of aberrant mitochondrial metabolism of LAC

L-carnitine and acetyl-L-carnitine enhance mitochondrial activity and energy metabolism by restoring the NAD(H)/NADP(H) ratio, thereby mitigating ROS-induced damage
[9] Across the board, the group receiving carnitine supplements showed lower cholesterol, lower fat mass, higher muscle mass, and significantly less physical and mental fatigue

However, the high-altitude hypoxic environment cannot meet the oxygen demands of spermatogenesis
