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This in turn results in NMDAR hypo-responsiveness and leads to a decline in cognitive function and neuropsychiatric symptoms [153]

Defined by hyperandrogenism, ovulatory dysfunction, insulin resistance, and chronic low-grade inflammation, PCOS, a common endocrine disorder in reproductive aged women causes irregular periods, infertility, excess androgens which collectively contributes toward long-term risks for serious conditions like type 2 diabetes, cardiovascular diseases, sleep apnea, depression, endometrial cancer and other reproductive complications underscoring the need for a comprehensive, multifaceted management strategy ( Figure 1 )

Neuroprotective Effects of Quercetin in Alzheimer's Disease. Biomolecules 10: 59

Gastric cancer screening and subsequent risk of gastric cancer: a large-scale population-based cohort study, with a 13-year follow-up in Japan