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Unlike other growth factors, which need carrier(s) addition, and are rapidly destroyed in human gastric juice, BPC 157 is native and stable in human gastric juice for more than 24 h (Sikiric et al., 2018

Consequently, many AML subtypes display marked dependence on cystine uptake mediated by the system xc- (SLC7A11) antiporter, which imports extracellular cystine for subsequent reduction to cysteine and incorporation into glutathione for antioxidant defense [46,47]

Grzelak et al., 2024)

This includes using OECD guideline GLP studies and screening studies optimised for testing with very low amounts of test substance, often with additional options to help determine the mode of action.