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Description
Nature 1997
Key structural alterations include disrupted mitochondrial morphology, severe ultrastructural damage, and depletion of mitochondrial DNA (mtDNA)
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Notably, neurons rely on astrocytes to supply precursors of the Krebs cycle intermediates, or their derivatives, as the enzyme pyruvate carboxylase is present in only astrocytes but not in neurons (Hertz et al., 1999)
