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Subregion specific neuroadaptations in the female rat striatum during acute and protracted withdrawal from nicotine
Induction of p53-mediated apoptosis and recovery of chemosensitivity through p53 transduction in human glioblastoma cells by cisplatin
Mechanistically, permeation enhancement is typically achieved through transient modulation of epithelial tight junctions to increase paracellular transport, alteration of membrane organisation to facilitate transcellular diffusion, and may also influence local mucus-drug interactions or enzymatic stability depending on excipient chemistry and exposure profile (Maher et al., 2019)
Similar results were observed in the present study, although the underlying mechanisms remain to be identified
