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Additionally, exposure of GV oocytes to either H 2 O 2 or 4-HNE resulted in decreased meiotic completion, increased spindle abnormalities, chromosome misalignments and aneuploidy

456 The CFMB nanoplatform, loaded with Metformin (MET) and BAY-876 (BAY) on CuFeO (CF), targets glycolysis and OXPHOS, depleting tumor energy via MET-mediated HK2 inhibition and mitochondrial disruption, and BAY-mediated GLUT1 inhibition

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doi: 10.1038/s41434-020-0141-0 220 YrigollenCMDavidsonBL