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enalapril is activated to enalaprilat, codeine is changed to morphine) or unchanged (diazepam is changed to nordiazepam)

Emerging strategies to increase the bioavailability and therapeutic efficacy of phytochemicals in cancer therapy Phytochemicals have high anticancer effects that are multi-targeted, regulating the activation of the PI3K/Akt, MAPK, and NF-kB signaling pathways, yet their use in the clinic is impacted by low aqueous solubility, chemical instability, low membrane permeability, and rapid metabolism [175, 309]

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Kumar S, Wang S, Wang M, Zeb S, Khan MN, Chen Y, Zhu G, Zhu Z (2024b) Enhancement of Sweetpotato tolerance to chromium stress through melatonin and glutathione: insights into photosynthetic efficiency, oxidative defense, and growth parameters