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Metastatic minimal-deviation melanoma

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In contrast to cutaneous melanoma, clear cell sarcomas invariably arise in the deep soft tissue of the distal extremities, and 70% possess a consistent balanced translocation t(12;22)(q13;q12) that is not found in melanoma and is believed to be an early, if not primary, event in tumorigenesis

Histopathologic slides were reviewed by an ophthalmic pathologist (C.L.) specializing in ocular and skin tumors, and the lesions were histologically classified into the following categories as defined by the 2018 WHO classification of tumours of the eye 6 (Fig