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Description
The results suggested that TB-500 not only potentially enhanced the viability, angiogenesis, and migratory ability of HUVEC but possibly also promoted the expression of angiopoietin-2 (Ang2), TEK receptor tyrosine kinase 2 (tie2), vascular endothelial growth factor A (VEGFA), NOTCH1 intracellular domain (N1ICD), Notch receptor 3 (Notch3), NF-B, and phosphorylated (p)-p65 in HUVEC

Reduces inflammation in the area of injury

The treatments provide both immediate and cumulative long-term benefits
Known substrates of VanAB indicate that a methoxy group in meta position to a carboxyl group is necessary for the activity of the enzyme [36]