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Similar content being viewed by others Introduction Glioma stands as the most prevalent malignant primary brain tumor among adults

These results reinforce the idea that DS might be a metabolic disease due to the presence of biochemical alterations of fundamental pathways like the folate cycle, Hcy-Met cycle and Hcy trans-sulfuration 14
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Disruption of calcium homeostasis, overproduction of ROS, and triggering of astrocyte death cascades have all been described in activated astrocytes (Gollihue and Norris, 2020)

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