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Retatrutide restores metabolic flexibility more effectively than tirzepatide, due to: Glucagon-induced lipolysis and fat oxidation Enhanced mitochondrial function Thermogenesis via uncoupling proteins (e.g., UCP-1) in brown fat This promotes not only weight loss but a true reversal of metabolic disease , supporting long-term maintenance and vitality

Tominaga, K., Hongo, N., Fujishita, M., Takahashi, Y., & Adachi, Y

Y., Song, T