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Description
Activation of mGluRs induces protein kinase C (PKC) phosphorylation and upregulates NMDAR function, leading to an increase in Ca 2+ influx, which acts as a pervasive and pluripotent second messenger ( 2+ triggers a cascade of reactions within cells to activate protein kinases, phosphatases, and nitric oxide synthase (NOS)
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in addition, loss of nhr-49 sensitizes worms to arsenite and paraquat (Horikawa and Sakamoto, 2009
