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Of the 35 enzymes tested, 17 were capable of cleaving the glucuronide moiety of estrone (E1-3G), and 15 were capable of cleaving the glucuronide of estradiol (E2-17G)
They are not a sedative or a benzodiazepine, so they do not usually cause strong drowsiness or dependence
Interdiscip Toxicol 2015;8:5564
