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10.1021/ml3003296 76 HoeselB.SchmidJ
There is significant evidence for nuclear hormone crosstalk in the development and treatment of hepatic steatosis

Nrf2 is activated by oxidative stress and increases the expression of numerous antioxidant response elements (AREs) and therefore the antioxidant capacity of the cell [21]
Long-term LAC supplementation reduces glucose metabolism to lactic acid, resulting in an increment in energy metabolites and changes in norepinephrine (NE), DA and serotonin (5-HT) in the brain of mice (96, 103)
