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In much of the clinical research, TB-500 is described as systemic supportmeaning its often framed as a peptide that can influence broader recovery signaling rather than only localized tissue effects

Are there any risks or side effects

In total, 76 patients with 79 cases of anaphylaxis were finally obtained after removing the duplicates, including 37 cases of anaphylactic shock and 42 cases of no anaphylaxis shock

"Two concentrations of topical tretinoin (retinoic acid) cause similar improvement of photoaging but different degrees of irritation: a double-blind, vehicle-controlled comparison of 0.1% and 0.025% tretinoin creams." Archives of dermatology 131.9 (1995): 1037-1044