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In the following chapters, we expounded on the molecular mechanisms of pyroptosis, ferroptosis, and autophagy, reviewed their studies in GBM over the last two years, and discussed how to best exploit these pathways to synergistically improve the effect of traditional or novel GBM treatment strategies

The IRE1 induces mRNA splicing and induces TNF-associated factor 2 (TRAF2), prompting inflammation/apoptosis (Rajapaksa et al., 2015)

A physician should also review diabetes medications, hydration status, kidney concerns, gallbladder history, gastrointestinal disease, thyroid history, current prescriptions, and long-term goals

NLA may enhance its antioxidant efficacy by more effectively modulating intracellular signaling pathways such as NRF2, thereby boosting the expression of antioxidant genes and increasing the activity of associated enzymes