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Simultaneously, physical activity initiates mitochondrial biogenesis (mediated by peroxisome proliferator-activated receptor gamma coactivator 1-alpha, PGC-1), enhances mitophagy, maintains the balance between mitochondrial fusion and fission, and optimizes electron transport chain efficiency, which collectively mitigates ROS production and safeguards the functionality of both muscle and endothelial cells (74)

These data lay the groundwork for functional studies into the role of this pathway in physiological and disease contexts in regulation of cell state via histone acetylation and viability and growth potential via lipid synthesis

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