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Guanine has the lowest redox potential among the four bases, making it more susceptible to be damaged from oxidative stress and form 8-oxoG

doi: 10.3389/fonc.2025.1712576 Received 24 September 2025 Revised 07 November 2025 Accepted 21 November 2025 Published 10 December 2025 Volume 15 - 2025 Edited by Egidio Iorio, National Institute of Health (ISS), Italy Reviewed by Leandro Jos de Assis, University of Plymouth, United Kingdom Rosa Anglica Castillo-Rodrguez, Instituto Politecnico Nacional, Mexico Updates Copyright 2025 Chung, Saad, Kafri, Rossignol, Verbrugge and Bakke

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