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5 Diagnosis Clinical presentation This is an adult onset disease with a clinical presentation that may be as subtle as a gradual development of exercise intolerance and weight loss

[4] Lipofuscin is also accepted as consisting of oxidized proteins (3070%) as well as lipids (2050%)

For example, AMPK activation can prevent the synthesis of fatty acids and cholesterol by upregulating the expression of genes involved in fatty acid oxidation and lipid decomposition, such as peroxisome proliferator-activated receptor coactivator 1 ( Pgc1 ) and adipose triglyceride lipase ( Atgl ), and by down-regulating the expression of adipogenesis genes such as FAS and ACC [181]
