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The brain consumes more oxygen than other organs, has more polyunsaturated fatty acids, and contains little catalase activity [38]

That means it's legally available only inside an approved clinical trial

Pharmacometabolomics as classically defined predicts the biologic outcome of a drug or xenobiotic based on mathematical modeling of preintervention metabolite signatures [54] but can also capitalize on comparisons between treated and untreated populations

low-dose decitabine-primed chemoimmunotherapy re-sensitized resistant cancer cells and showing promising safety and efficacy in ESCC patients, suggesting DNMT inhibitor as a potential therapeutic agent in relapsed/refractory ESCC patients [140]