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a 2026 orthopaedics review confirms receptor desensitization is a recognized effect of prolonged or high-frequency use (JAAOS Global, 2026)
The continuous turnover of synovial fluid leads to a short residence time for the administered peptides in the joint space, whereas the dense, negatively charged cartilage matrix impedes their diffusive transport
The agency says the committee will discuss bulk drug substances being considered for inclusion on the 503A Bulks List
