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3 Results 3.1 CB-839 treatment inhibits glutathione synthesis and the conversion of glutamine to glutamate in CLL cell lines Initially, we investigated CB-839s functional inhibition of GLS-1 ( Figures 1A, B )
A drug can be metabolized in the gut wall (eg, by the CYP3A4 enzyme system) or even in the portal blood, but most commonly it is the liver that is responsible for metabolism before the drug reaches the systemic circulation
GDF15: a hormone conveying somatic distress to the brain
