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When exercise inhibits the Akt/mTORC1 - SREBP-1 pathway, it can reduce the expression and activity of SREBP-1, thereby diminishing the transcriptional activation of lipogenic genes like ACC and FAS, leading to decreased hepatic lipid synthesis and accumulation [49]

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Compared with 5-FU alone, the combination treatment (i.e., 5-FU + RSL3) significantly suppressed tumor regrowth after 5-FU cessation ( Figures 5FH )