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Abbas HA, Ayoub E, Sun H, Kanagal-Shamanna R, Short N, Issa GC, Yilmaz M, Pierce SA, Rivera D, Cham B, Wing S, Li Z, Hammond D, Jabbour E, Borthakur G, Garcia-Manero G, Andreeff M , Daver N, Kadia TM, Konopleva M, DiNardo CD, and Ravandi F

To confirm whether selenomethionine can be converted into selenocysteine through the transsulfuration pathway to regulate the protein levels of GPX4, we detected the GPX4 of OS-RC-2, HepG2, and HT1080 cultured in medium with or without selenomethionine, cystine or RSL3

The most prescribed antidepressants, selective serotonin reuptake inhibitors (SSRIs), directly target the serotonin system, more specifically the serotonin transporter (SERT), on a rationale built upon the monoamine hypothesis of depression 4

GKT137831 has demonstrated potential in preclinical studies to reduce cardiovascular complications, but current clinical trials on this agent lack evaluation of macrovascular outcomes, highlighting the need for longer-term studies in this setting