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By activating GPx3, Brazil nuts specifically protect against the critical oxidation step that makes LDL atherogenic

Nuclear factor-kappa B (NF-B) is a transcription factor that binds DNA and induces the transcription of the COX-2 gene, other pro-inflammatory genes, as well as genes involved in cell proliferation, adhesion, survival, and differentiation

The catenation of sulfur atoms endows supersulfides with unique reactivity as it positions them as critical regulators in various biological processes, such as enzyme activity, oxidative stress response, energy metabolism, pathogen infection, and immune modulation (1517) ( Figure 1 )

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