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Acknowledgments The author would like to thank all the authors for their contributions to this article

However, VEGF-signaling inhibition commonly results in the partial clearance of cancer cells, and in certain patients, cancer recurrence may occur, compromising overall survival

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But, there are several reports supporting an association between inadequate B12 levels and premature hair graying, which is grey hair that onsets before the ages of 20-30 (depending on the demographic) (12)