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Similarly, recruitment of participants with severe hepatic impairment into the hepatic impairment study was challenging and, despite a third study site being added and the recruitment period being prolonged, it was not possible to complete recruitment of seven participants into the severe hepatic impairment group

In addition, cell autonomous primary astrocytopathies can give rise to aberrant astrocytes which drive neuropathological progression, and there is now mounting interest in how astrocytes that are reactive or diseased might have detrimental effects on the outcome of disorders

Carmona, D

elegans (Shoup and Priola, 2025)
