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This work was supported by grants from the Fundao de Amparo Pesquisa do Estado de So Paulo (FAPESP) (#2015/03756-4 and 2018/09937-9) and Conselho Nacional de Desenvolvimento Cientfico e Tecnolgico (CNPq) (303422/2015-7)

This may indicate that they could enhance the toxicity of methotrexate

Just make sure you have the need for hydration (don't do this prior to running), and that electrolytes are dialed in to prevent hyponatremia

Future advancements require interdisciplinary collaboration, integrating immunotherapy, ferroptosis inducers, TCM, and nanotechnology to refine treatments and accelerate clinical translation