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These results suggested that PRMT1 regulated fatty acid metabolism by methylating UBE2m at R169
doi: 10.1016/S0005-2736(02)00457-1
To support the safety of this supplement, another study analyzed the effects of oral SAM-e and found that it works rapidly at the onset of action, has negligible side effects, and can be used as a safe antidepressant treatment (De Vanna & Rigamonti, 1992)
doi: 10.1161/JAHA.113.000755
