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Transcriptomic analyses also indicate that elevated oxidative stress changes gene expression profiles in RPE cells, stimulating pathways that contribute to cellular senescence, angiogenesis and complement malfunction (216, 217)

Reprogramming science The discovery of the reprogramming recipe earned a Nobel Prize for Japanese biologist Shinya Yamanaka in 2012

Significant myelin and axonal damage have also been detected in HD (Di Paola et al., 2012) and may underlie the WM changes observed in this condition
ACD can serve as a tumor suppressor, which clears damaged cells, but dysregulated autophagy can also convey tumor progression or therapy resistance (Patra et al
