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A scoping review in Cureus (2025) added important context: dual-acting agonists like tirzepatide which targets both GLP-1 and GIP receptors produced greater reductions in weight and insulin sensitivity than GLP-1-only agents
Periodic screening for vitamin B12 deficiency should be considered, especially in patients with peripheral neuropathy or macrocytic anemia
Research on animals suggests that Lrrk2 p.G2019S mice had more severe colitis than controls, which results in decreased motor function and death of dopaminergic neurons (97)
Decreased levels of NAD + have been associated with dyslipidemia
