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USA 93 , 19561961 (1996)

Additionally, oxidative stress significantly impairs RFC function: Low glutathione: Reduces RFC function ~20-40% High nitric oxide: Reduces RFC function ~35% Hyperglycemia: Reduces RFC function ~20-35% Even if you're taking Leucovorin, oxidative stress can prevent it from reaching your brain

Yao et al., 2006

Additionally, the activity of nuclear factor E2-related factor 2 (NRF2) increases, thereby preventing ferroptosis
