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doi: 10.1111/j.2047-2927.2013.00107.x

These region-specific imbalances ultimately manifest as characteristic alterations in plasma and urinary carnitine/acylcarnitine profiles

It is postulated that clinical symptoms, including CNS complications such as convulsion, coma and lethargy, may be triggered by the accumulation of metabolites and their acyl-CoA derivatives that disrupt intermediary metabolism [6669]

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