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coli BL21 was performed to overexpress catalase, followed by nanoscale acoustic-sensitized particles PCN synthesized from acoustic-sensitizing molecules tetrakis (4-carboxyphenyl) porphyrin (TCPP) and zirconium clusters (Zr6) NPs was adsorbed onto the bacterial surface by electrostatic interaction to obtain the multifunctional biohybrid E.coli -pE@PCN

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