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In addition to stem cell self-renewal, NRF2 participates in human embryonic stem cells differentiation into neuroectoderm (63)

Recent research has indicated that the heightened neurotoxicity linked to the overexpression of P2X4R plays a significant role in the pathological mechanisms of neurodegenerative conditions, including injury, inflammation, Alzheimers disease, Parkinsons disease, and multiple sclerosis (Ma et al., 2020)

For several other biologically relevant metals, thiol-bound forms were postulated to form, or actually highlighted by ex vivo in vitro experiments that were performed mainly on whole blood or in isolated red blood cells

BPAs metabolites are genotoxic, reacting and depurinating guanosine and adenosine [89]