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Moreover, while OCCC show intrinsic resistance to conventional platinum-based chemotherapy, OSC exhibit at first sensitiveness to platinum-based chemotherapy, though the majority of cases develop chemoresistance during the course of treatments 33,34
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Since dopamine has been associated with locomotor deficits, it can be speculated that its regulatory role on dopamine might have contributed to the improvement in locomotor activity
that is how allostery signals
