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The Cellular Redox System The cellular redox state refers to the balance between oxidation and reduction reactions (Calabrese et al., 2010
3.3 Nrf2 pathway Nrf2 assumes a critical role by activating the body's antioxidant response through binding to antioxidant response elements (ARE) in the promoter regions of numerous genes responsible for cellular protection (48)
Furthermore, our group has discovered novel oxidation hotspots, including His10 and Leu17 in the B-chain, and Cys6 in the alpha-chain (87)
