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Untreated vitamin B12 deficiency can lead to various physical, neurological, and psychological issues

Hum DW, Belanger A, Levesque E, Barbier O, Beaulieu M, Albert C et al

Via base-pairing with specific sequences of target genes typically found in mRNA 3 untranslated regions (3UTRs), they usually result in gene silencing via translational repression or target mRNA degradation by an RNA-induced silencing complex consisting of Argonaute catalytic subunits (Ago1 in Drosophila ) 25,26

Gastrointestinal Symptoms : nausea, vomiting, diarrhea, constipation, abdominal pain, reflux, heartburn, and impaired motility Secretomotor Symptoms : difficulty sweating, tearing, and other fluid production (dry eyes, dry mouth, difficulty swallowing, dry skin)