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In this study, we investigated the possible neurotoxic effects elicited by 72 h exposure to spike protein (recombinant S1 + S2), toxin-like peptides found in symptomatic COVID-19 patients, and a combination of both on short- and long-term differentiated cultures of human iPSC-derived neural stem cells (NSCs) differentiated towards a mixed culture of neurons/glia as 3D neurospheres, as previously described [55]
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Intramuscular vitamin B12 delivered into the deltoid muscle ensures 100% bioavailability, allowing rapid restoration of depleted cellular stores and immediate symptom relief
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