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Clinicians should avoid administration in patients with elevated prostate-specific antigen without urologic evaluation, and those with poorly controlled thrombophilia, since androgen-induced rises in hematocrit and platelet activation may amplify thromboembolic risk
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This suggests DSIP acts as a chronobiological organizer
Lu and Klaassen, 2008) and some evidence points to a progesterone and/or dehydroepiandrosterone regulation of this sex difference (Rost et al., 2005
