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276 In an uncontrolled clinical trial in 28 women with fibromyalgia, 1,000 mcg of vitamin B12 daily for 50 days reduced symptom severity and anxiety scores
tl;dr More medical studies are needed, but up to 2 grams a day seems safe for most people

doi: 10.3233/JAD-161141 117 JochemsJ.BouldenJ.LeeB
However, the identity of the kinase responsible for the priming phosphorylation at S114 and the precise mechanism by which this modification triggers protein turnover remains unclear