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Heffernan 2001b This metabolic selectivity has a dosage implication: once the beta-3 receptors in adipose tissue are adequately occupied, additional peptide does not proportionally increase the lipolytic signal

It inhibits gastric emptying and glucagon secretion as well as decreases meal size and calorie intake (fat specific) (197) in a dose-dependent manner

Symptoms following acute NSAID overdose are usually limited to lethargy, drowsiness, nausea, vomiting and epigastric pain, gastrointestinal bleeding can occur but very rarely, hypertension, acute renal failure, respiratory depression and coma