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Yzydorczyk C, Li N, Rigal E, Chehade H, Mosig D, Armengaud JB, Rolle T, Krishnasamy A, Orozco E, Siddeek B, Juvet C, Vergely C, Simeoni U (2019) Calorie restriction in adulthood reduces hepatic disorders induced by transient postnatal overfeeding in mice

In parallel, inflammatory responses are rapidly initiated, with activation of microglia, infiltration of peripheral immune cells, and production of pro-inflammatory cytokines like TNF- and IL-1, further exacerbating tissue damage (26)

Consequently, its deficiency state relates to low-grade inflammation

But it does suggest that vegans following VeganHealths recommendations are absorbing considerably less B12 than those associated with elevated risk in the observational literature