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C., Moguel-Ordonez, Y

The rapid proliferation of glioma causes an arduous microenvironment such as acidity, limited of nutrients, and oxygen (47, 93, 94)

The therapeutic activity of NAC relies on its ability to provide reducing sulfhydryl moieties and to act as a precursor of GSH to replenish the intracellular GSH pool when this has been depleted in conditions of oxidative stress, in processes of drug detoxification, or in other conditions leading to GSH deficit

Oral supplements are also more practical for long-term maintenance.
