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Conversely, progranulin and its derivative peptide atsttrin can bind to the TNF receptors to inhibit the phenotype and function associated with LPS-induced M1 macrophage polarization via the nuclear factor kappa-B (NF-B) and MAPK signaling pathways [49]

Caspase-3 suppression: The "executioner" enzyme of apoptosis was reduced by 42.7%, directly blocking the cell death cascade
Effect of tesamorelin on visceral fat and liver fat in HIV-infected patients with abdominal fat accumulation: a randomized clinical trial
