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observed that APS stimulate KCs by decreasing the amounts of recombinant autophagy-related proteins (ATGs), family members (ATG7, ATG12, and ATG6), and protein II light chain 3 (LC3II), resulting in a decrease in CD68-positive KCs ( 3 Conclusion and Future Perspectives As phytotherapy, APS are appropriate for long-term therapeutic options in patients with chronic illness owing to relatively small toxic side effects, which has been the most difficult issue in the study of NAFLD treatments, resulting in a large number of medicines being abandoned in subsequent clinical trials

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MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis