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This is by increasing tight junction protein ZO-1 expression and transepithelial resistance [6], inhibiting the mRNA of inflammatory mediators (iNOS, IL-6, IFN, and TNF-alpha), and increasing the expression of HSP 70 and 90 and antioxidant proteins [6]

Mucin production also contributes to barrier integrity due to its importance in building the mucosal layer

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