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Strategies like ligand-mediated uptake or intestinal permeation enhancers can enhance gut absorption

At the mitochondrial level, these compounds regulate apoptotic signaling by increasing the expression of anti-apoptotic proteins such as B-cell lymphoma 2 (Bcl-2) and B-cell lymphoma-extra-large (Bcl-xL), while decreasing pro-apoptotic proteins including Bcl-2associated X protein (Bax) and Bcl-2associated agonist of cell death (Bad)

In this context, NSAIDs, for example, are widely employed owing to their ability to inhibit cyclooxygenase (COX-1 and COX-2) enzymes

doi: 10.1016/S0377-1237(10)80115-7
