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Neutralized nanoparticle composed of SS-cleavable and pH-activated lipid-like material as a long-lasting and liver-specific gene delivery system

This discussion compares tripeptides, exemplified by the well-studied GHK, with larger peptides such as the cyclic heptapeptide CyRL-QN15, the human cathelicidin-derived antimicrobial peptide LL-37, and the peptide Andersonin W-1 (AW1), containing 7, 37, and 72 amino acids, respectively [25, 67, 68]

79 YarmolinskyD.BrychkovaG.FluhrR.SagiM

Lyophilized peptides lack the aqueous environment required for rapid hydrolysis, making them far more forgiving during accidental temperature excursions